Reviews of Reproduction
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS  
Reviews of Reproduction (1999) 4 135-142
© 1999 Society for Reproduction and Fertility
DOI: 10.1530/ror.0.0040135
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brewis, I.
Right arrow Articles by Wong, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brewis, I.
Right arrow Articles by Wong, C.

Articles

Gamete recognition: sperm proteins that interact with the egg zona pellucida

IA Brewis and CH Wong

The gamete recognition and initial binding processes that are crucial for the success of mammalian fertilization are mediated by moieties associated with the extracellular matrix of the egg (the zona pellucida) and the head of the fertilizing spermatozoon. The zona proteins involved have been characterized in some detail, with ZP3 and ZP2 generally acknowledged to be responsible for the initial (primary) and secondary interactions, respectively. However, the identity of the complementary molecules on the sperm surface is highly contentious and remains unresolved. This review summarizes the current knowledge and controversies in this research area. The credentials of some of the major candidates and the probability of the involvement of multiple sperm receptors with different binding characteristics are assessed. Resolving this very important gap in our understanding is an essential prerequisite to understanding fully the molecular and signal transduction events that cause sperm acrosomal exocytosis. Such fundamental information is also imperative for the development of novel forms of contraception (or sterilization) targeted against specific sperm epitopes. Moreover, this information may contribute to our understanding of certain types of male infertility.


This article has been cited by other articles:


Home page
 Mol Hum ReprodHome page
R. A. van Gestel, I. A. Brewis, P. R. Ashton, J. F. Brouwers, and B. M. Gadella
Multiple proteins present in purified porcine sperm apical plasma membranes interact with the zona pellucida of the oocyte
Mol. Hum. Reprod., July 1, 2007; 13(7): 445 - 454.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
K. L. Pixton, E. D. Deeks, F. M. Flesch, F. L.C. Moseley, L. Bjorndahl, P. R. Ashton, C. L.R. Barratt, and I. A. Brewis
Sperm proteome mapping of a patient who experienced failed fertilization at IVF reveals altered expression of at least 20 proteins compared with fertile donors: Case report
Hum. Reprod., June 1, 2004; 19(6): 1438 - 1447.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
T. Hemachand, B. Gopalakrishnan, D. M. Salunke, S. M. Totey, and C. Shaha
Sperm plasma-membrane-associated glutathione S-transferases as gamete recognition molecules
J. Cell Sci., May 15, 2002; 115(10): 2053 - 2065.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
L. He, J.L. Bailey, and M.M. Buhr
Incorporating Lipids into Boar Sperm Decreases Chilling Sensitivity but Not Capacitation Potential
Biol Reprod, January 1, 2001; 64(1): 69 - 79.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
A. Miranda-Vizuete, J. Ljung, A. E. Damdimopoulos, J.-A. Gustafsson, R. Oko, M. Pelto-Huikko, and G. Spyrou
Characterization of Sptrx, a Novel Member of the Thioredoxin Family Specifically Expressed in Human Spermatozoa
J. Biol. Chem., August 17, 2001; 276(34): 31567 - 31574.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS  
Copyright © 1999 by the Society for Reproduction and Fertility.