Reviews of Reproduction
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS  

Reviews of Reproduction (1999) 4 151-159
© 1999 Society for Reproduction and Fertility
DOI: 10.1530/ror.0.0040151
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Permissions information
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Breitbart, H
Right arrow Articles by Naor, Z
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Breitbart, H
Right arrow Articles by Naor, Z
Social Bookmarking
 Add to CiteULike   Add to Complore   Add to Connotea   Add to Delicious   Add to Digg   Add to Facebook   Add to LinkedIn   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Articles

Protein kinases in mammalian sperm capacitation and the acrosome reaction

H Breitbart and Z Naor

Binding to the zona pellucida of an egg stimulates the spermatozoon to undergo the acrosome reaction, a process that enables it to penetrate the egg. Before this binding, the spermatozoon undergoes a series of biochemical transformations in the female reproductive tract, collectively called capacitation. Only capacitated spermatozoa can bind to the zona pellucida and undergo the acrosome reaction. Protein kinases may be involved in the regulation of intracellular Ca2+ during capacitation and the acrosome reaction. The first event in capacitation is the increase in intracellular calcium, bicarbonate and hydrogen peroxide, which collectively activate adenylyl cyclase to produce cyclic AMP, which activates protein kinase A to phosphorylate certain proteins. During capacitation, there is an increase in membrane-bound phospholipase C, and this binding is highly stimulated by the addition of epidermal growth factor to the cells. The capacitated spermatozoon binds to the zona pellucida of the egg via specific receptors and it is suggested that the zona pellucida binds to at least two different receptors in the sperm head plasma membrane. One is a Gi-coupled receptor that can activate phospholipase Cbeta1 and may regulate adenylyl cyclase to further increase cyclic AMP concentrations. The cyclic AMP activates protein kinase A to open a calcium channel in the outer acrosomal membrane, resulting in a relatively small increase in cytosolic calcium. This increase in Ca2+ leads to activation of phospholipase Cgamma, which is coupled to the second tyrosine kinase receptor. The products of phosphatidyl-inositol bisphosphate hydrolysis by phospholipase C, diacylglycerol and inositol-trisphosphate, induce the activation of protein kinase C and a calcium channel in the outer acrosomal membrane, respectively. Protein kinase C opens a calcium channel in the plasma membrane and, together with the inositol-trisphosphate-activated calcium channel, leads to a second and higher increase in cytosolic calcium. In addition, the depletion of calcium in the acrosome activates a capacitative calcium entry mechanism in the plasma membrane, leading to a rapid increase in cytosolic calcium (300-500 nmol l(-1)). This increase in intracellular calcium concentration (and pH) leads to membrane fusion and the acrosome reaction.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Delicious Delicious   Add to Digg Digg   Add to Facebook Facebook   Add to LinkedIn LinkedIn   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
Biol. Reprod.Home page
M. Tourmente, P. Villar-Moya, M. Varea-Sanchez, J. J. Luque-Larena, E. Rial, and E. R. S. Roldan
Performance of Rodent Spermatozoa Over Time Is Enhanced by Increased ATP Concentrations: The Role of Sperm Competition
Biol Reprod, September 1, 2015; 93(3): 64 - 64.
[Abstract] [Full Text] [PDF]


Home page
Biol. Reprod.Home page
B. Leemans, B. M. Gadella, E. Sostaric, H. Nelis, T. A. E. Stout, M. Hoogewijs, and A. Van Soom
Oviduct Binding and Elevated Environmental pH Induce Protein Tyrosine Phosphorylation in Stallion Spermatozoa
Biol Reprod, July 1, 2014; 91(1): 13 - 13.
[Abstract] [Full Text] [PDF]


Home page
ReproductionHome page
H. Rotfeld, P. Hillman, D. Ickowicz, and H. Breitbart
PKA and CaMKII mediate PI3K activation in bovine sperm by inhibition of the PKC/PP1 cascade
Reproduction, March 1, 2014; 147(3): 347 - 356.
[Abstract] [Full Text] [PDF]


Home page
Biol. Reprod.Home page
S. Tapia, M. Rojas, P. Morales, M. A. Ramirez, and E. S. Diaz
The Laminin-Induced Acrosome Reaction in Human Sperm Is Mediated by Src Kinases and the Proteasome
Biol Reprod, August 1, 2011; 85(2): 357 - 366.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
T. Veitinger, J. R. Riffell, S. Veitinger, J. M. Nascimento, A. Triller, C. Chandsawangbhuwana, K. Schwane, A. Geerts, F. Wunder, M. W. Berns, et al.
Chemosensory Ca2+ Dynamics Correlate with Diverse Behavioral Phenotypes in Human Sperm
J. Biol. Chem., May 13, 2011; 286(19): 17311 - 17325.
[Abstract] [Full Text] [PDF]


Home page
ReproductionHome page
T. Rotman, N. Etkovitz, A. Spiegel, S. Rubinstein, and H. Breitbart
Protein kinase A and protein kinase C{alpha}/PPP1CC2 play opposing roles in the regulation of phosphatidylinositol 3-kinase activation in bovine sperm
Reproduction, July 1, 2010; 140(1): 43 - 56.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
L. Suhaiman, G. A. De Blas, L. M. Obeid, A. Darszon, L. S. Mayorga, and S. A. Belmonte
Sphingosine 1-Phosphate and Sphingosine Kinase Are Involved in a Novel Signaling Pathway Leading to Acrosomal Exocytosis
J. Biol. Chem., May 21, 2010; 285(21): 16302 - 16314.
[Abstract] [Full Text] [PDF]


Home page
J. Cell Sci.Home page
F. Ackermann, N. Zitranski, H. Borth, T. Buech, T. Gudermann, and I. Boekhoff
CaMKII{alpha} interacts with multi-PDZ domain protein MUPP1 in spermatozoa and prevents spontaneous acrosomal exocytosis
J. Cell Sci., December 15, 2009; 122(24): 4547 - 4557.
[Abstract] [Full Text] [PDF]


Home page
Biol. Reprod.Home page
M. Lemoine, J. Dupont, V. Guillory, S. Tesseraud, and E. Blesbois
Potential Involvement of Several Signaling Pathways in Initiation of the Chicken Acrosome Reaction
Biol Reprod, October 1, 2009; 81(4): 657 - 665.
[Abstract] [Full Text] [PDF]


Home page
Biol. Reprod.Home page
M. Kong, E. S. Diaz, and P. Morales
Participation of the Human Sperm Proteasome in the Capacitation Process and Its Regulation by Protein Kinase A and Tyrosine Kinase
Biol Reprod, May 1, 2009; 80(5): 1026 - 1035.
[Abstract] [Full Text] [PDF]


Home page
ReproductionHome page
P. Grasa, C. Colas, M. Gallego, L. Monteagudo, T. Muino-Blanco, and J. A. Cebrian-Perez
Changes in content and localization of proteins phosphorylated at tyrosine, serine and threonine residues during ram sperm capacitation and acrosome reaction
Reproduction, April 1, 2009; 137(4): 655 - 667.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
T. Almog, S. Lazar, N. Reiss, N. Etkovitz, E. Milch, N. Rahamim, M. Dobkin-Bekman, R. Rotem, M. Kalina, J. Ramon, et al.
Identification of Extracellular Signal-regulated Kinase 1/2 and p38 MAPK as Regulators of Human Sperm Motility and Acrosome Reaction and as Predictors of Poor Spermatozoan Quality
J. Biol. Chem., May 23, 2008; 283(21): 14479 - 14489.
[Abstract] [Full Text] [PDF]


Home page
ReproductionHome page
Y. Bastian, A. Zepeda-Bastida, S. Uribe, and A. Mujica
In spermatozoa, Stat1 is activated during capacitation and the acrosomal reaction
Reproduction, September 1, 2007; 134(3): 425 - 433.
[Abstract] [Full Text] [PDF]


Home page
Biol. Reprod.Home page
H. Yang, L. Hazlewood, S. J. Heater, P. A. Guerrero, R. B. Walter, and T. R. Tiersch
Production of F1 Interspecies Hybrid Offspring with Cryopreserved Sperm from a Live-Bearing Fish, the Swordtail Xiphophorus helleri
Biol Reprod, March 1, 2007; 76(3): 401 - 406.
[Abstract] [Full Text] [PDF]


Home page
ReproductionHome page
P. Grasa, J. A. Cebrian-Perez, and T. Muino-Blanco
Signal transduction mechanisms involved in in vitro ram sperm capacitation.
Reproduction, November 1, 2006; 132(5): 721 - 732.
[Abstract] [Full Text] [PDF]


Home page
ReproductionHome page
K Ashizawa, G J Wishart, S Katayama, D Takano, A R A H Ranasinghe, K Narumi, and Y Tsuzuki
Regulation of acrosome reaction of fowl spermatozoa: evidence for the involvement of protein kinase C and protein phosphatase-type 1 and/or -type 2A.
Reproduction, June 1, 2006; 131(6): 1017 - 1024.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
M. T. Branham, L. S. Mayorga, and C. N. Tomes
Calcium-induced Acrosomal Exocytosis Requires cAMP Acting through a Protein Kinase A-independent, Epac-mediated Pathway
J. Biol. Chem., March 31, 2006; 281(13): 8656 - 8666.
[Abstract] [Full Text] [PDF]


Home page
Genes Dev.Home page
Y. Gur and H. Breitbart
Mammalian sperm translate nuclear-encoded proteins by mitochondrial-type ribosomes
Genes & Dev., February 15, 2006; 20(4): 411 - 416.
[Abstract] [Full Text] [PDF]


Home page
ReproductionHome page
K Ashizawa, G J Wishart, S Katayama, D Takano, M Maeda, E Arakawa, and Y Tsuzuki
Effects of calpain and Rho-kinase inhibitors on the acrosome reaction and motility of fowl spermatozoa in vitro
Reproduction, January 1, 2006; 131(1): 71 - 79.
[Abstract] [Full Text] [PDF]


Home page
ReproductionHome page
K Ashizawa, G J Wishart, A R A H Ranasinghe, S Katayama, and Y Tsuzuki
Protein phosphatase-type 2B is involved in the regulation of the acrosome reaction but not in the temperature-dependent flagellar movement of fowl spermatozoa
Reproduction, December 1, 2004; 128(6): 783 - 787.
[Abstract] [Full Text] [PDF]


Home page
Biol. Reprod.Home page
H. Nishizono, M. Shioda, T. Takeo, T. Irie, and N. Nakagata
Decrease of Fertilizing Ability of Mouse Spermatozoa after Freezing and Thawing Is Related to Cellular Injury
Biol Reprod, September 1, 2004; 71(3): 973 - 978.
[Abstract] [Full Text] [PDF]


Home page
Biol. Reprod.Home page
S. Delle Monache, F. Flori, C. Della Giovampaola, A. Capone, G.B. La Sala, F. Rosati, R. Colonna, C. Tatone, and R. Focarelli
Gp273, the Ligand Molecule for Sperm-Egg Interaction in the Bivalve Mollusk, Unio elongatulus, Binds to and Induces Acrosome Reaction in Human Spermatozoa Through a Protein Kinase C-Dependent Pathway
Biol Reprod, December 1, 2003; 69(6): 1779 - 1784.
[Abstract] [Full Text] [PDF]


Home page
Biol. Reprod.Home page
K. P. Roberts, J. A. Wamstad, K. M. Ensrud, and D. W. Hamilton
Inhibition of Capacitation-Associated Tyrosine Phosphorylation Signaling in Rat Sperm by Epididymal Protein Crisp-1
Biol Reprod, August 1, 2003; 69(2): 572 - 581.
[Abstract] [Full Text] [PDF]


Home page
Biol. Reprod.Home page
E. Brener, S. Rubinstein, G. Cohen, K. Shternall, J. Rivlin, and H. Breitbart
Remodeling of the Actin Cytoskeleton During Mammalian Sperm Capacitation and Acrosome Reaction
Biol Reprod, March 1, 2003; 68(3): 837 - 845.
[Abstract] [Full Text] [PDF]


Home page
Biol. Reprod.Home page
L. He, J.L. Bailey, and M.M. Buhr
Incorporating Lipids into Boar Sperm Decreases Chilling Sensitivity but Not Capacitation Potential
Biol Reprod, January 1, 2001; 64(1): 69 - 79.
[Abstract] [Full Text]


Home page
Biol. Reprod.Home page
M. Garbi, S. Rubinstein, Y. Lax, and H. Breitbart
Activation of Protein Kinase C{alpha} in the Lysophosphatidic Acid-Induced Bovine Sperm Acrosome Reaction and Phospholipase D1 Regulation
Biol Reprod, November 1, 2000; 63(5): 1271 - 1277.
[Abstract] [Full Text]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS  
Copyright © 1999 by the Society for Reproduction and Fertility.