Role of insulin-like growth factor binding protein 1 in human pregnancy

Insulin-like growth factors and their binding proteins are key regulators of fetal and maternal tissue growth and development during human pregnancy. Insulin-like growth factors, particularly IGF-II, are produced in abundance by the trophoblast cells of the placenta, whereas one of the insulin-like growth factor binding proteins, IGFBP-1, is the major secretory product of the maternal decidualized endometrium. This spatial (and temporal expression) of the insulin-like growth factor axis infers a sophisticated paracrine regulatory mechanism for controlling insulin-like growth factor function. This paper reviews the potential roles of IGFBP-1 in human pregnancy by examining its effects on growth, metabolism and migration at the maternal-fetal interface and how these might be influenced by autocrine-paracrine post-translational modifications.

This article has been cited by other articles:

				O. Shynlova, P. Tsui, A. Dorogin, B. L. Langille, and S. J. Lye Insulin-like Growth Factors and Their Binding Proteins Define Specific Phases of Myometrial Differentiation During Pregnancy in the Rat Biol Reprod, April 1, 2007; 76(4): 571 - 578. [Abstract] [Full Text] [PDF]

				V. E. Murphy, R. Smith, W. B. Giles, and V. L. Clifton Endocrine Regulation of Human Fetal Growth: The Role of the Mother, Placenta, and Fetus Endocr. Rev., April 1, 2006; 27(2): 141 - 169. [Abstract] [Full Text] [PDF]

				A. Jasinska, V. Han, A. T. Fazleabas, and J. J. Kim Induction of Insulin-Like Growth Factor Binding Protein-1 Expression in Baboon Endometrial Stromal Cells by Cells of Trophoblast Origin Reproductive Sciences, September 1, 2004; 11(6): 399 - 405. [Abstract] [PDF]

				J. Fuglsang, F. Lauszus, A. Flyvbjerg, and P. Ovesen Erratum J. Clin. Endocrinol. Metab., October 1, 2003; 88(10): 5042 - 5042. [Abstract] [Full Text] [PDF]

				J. Fuglsang, F. Lauszus, A. Flyvbjerg, and P. Ovesen Human Placental Growth Hormone, Insulin-Like Growth Factor I and -II, and Insulin Requirements during Pregnancy in Type 1 Diabetes J. Clin. Endocrinol. Metab., September 1, 2003; 88(9): 4355 - 4361. [Abstract] [Full Text] [PDF]