Reviews of Reproduction

Reviews of Reproduction (1999) 4 179-183
© 1999 Society for Reproduction and Fertility
DOI: 10.1530/ror.0.0040179
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Permissions information
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mahendroo, M.
Right arrow Articles by Russell, D.
Right arrow Search for Related Content
Right arrow PubMed Citation
Right arrow Articles by Mahendroo, M.
Right arrow Articles by Russell, D.
Social Bookmarking
 Add to CiteULike   Add to Complore   Add to Connotea   Add to Delicious   Add to Digg   Add to Facebook   Add to LinkedIn   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?


Male and female isoenzymes of steroid 5alpha-reductase

MS Mahendroo and DW Russell

There are two steroid 5alpha-reductase isoenzymes, designated type 1 and type 2, in mammals and recent experiments show that each plays a unique physiological role. In this article, the hypothesis is developed that the type 1 gene specifies a female isoenzyme, whereas the type 2 gene specifies a male isoenzyme. This idea results from the following observations. First, mutation of the 5alpha-reductase type 1 gene in mice affects reproduction in females by decreasing fecundity and blocking parturition, but has no effect on reproduction in males. Second, mutation of the 5alpha-reductase type 2 gene in mice and men prevents proper virilization but does not affect development or reproductive function in females. Analyses of these diverse phenotypes indicate that the isoenzymes catalyse both anabolic and catabolic reactions in steroid hormone metabolism.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Delicious Delicious   Add to Digg Digg   Add to Facebook Facebook   Add to LinkedIn LinkedIn   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?

This article has been cited by other articles:

Home page
J EndocrinolHome page
C. J. Corbin, E. L. Legacki, B. A. Ball, K. E. Scoggin, S. D. Stanley, and A. J. Conley
Equine 5{alpha}-reductase activity and expression in epididymis
J. Endocrinol., August 23, 2016; 231(1): 23 - 33.
[Abstract] [Full Text] [PDF]

Home page
Hum Reprod UpdateHome page
S. Makieva, P. T. K. Saunders, and J. E. Norman
Androgens in pregnancy: roles in parturition
Hum. Reprod. Update, July 1, 2014; 20(4): 542 - 559.
[Abstract] [Full Text] [PDF]

Home page
Proc. Natl. Acad. Sci. USAHome page
E. L. Scholtz, S. Krishnan, B. A. Ball, C. J. Corbin, B. C. Moeller, S. D. Stanley, K. J. McDowell, A. L. Hughes, D. P. McDonnell, and A. J. Conley
Pregnancy without progesterone in horses defines a second endogenous biopotent progesterone receptor agonist, 5{alpha}-dihydroprogesterone
PNAS, March 4, 2014; 111(9): 3365 - 3370.
[Abstract] [Full Text] [PDF]

Home page
Toxicol SciHome page
K. Ko, H. M. Theobald, R. W. Moore, and R. E. Peterson
Evidence that Inhibited Prostatic Epithelial Bud Formation in 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Exposed C57BL/6J Fetal Mice Is Not Due to Interruption of Androgen Signaling in the Urogenital Sinus
Toxicol. Sci., June 1, 2004; 79(2): 360 - 369.
[Abstract] [Full Text] [PDF]

Home page
Hum ReprodHome page
C.A. Hodges, A. Ilagan, D. Jennings, R. Keri, J. Nilson, and P.A. Hunt
Experimental evidence that changes in oocyte growth influence meiotic chromosome segregation
Hum. Reprod., May 1, 2002; 17(5): 1171 - 1180.
[Abstract] [Full Text] [PDF]

Copyright © 1999 by the Society for Reproduction and Fertility.