Reviews of Reproduction
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS  

Reviews of Reproduction (2000) 5 75-83
© 2000 Society for Reproduction and Fertility
DOI: 10.1530/ror.0.0050075
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Permissions information
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Blobel, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Blobel, C.
Social Bookmarking
 Add to CiteULike   Add to Complore   Add to Connotea   Add to Delicious   Add to Digg   Add to Facebook   Add to LinkedIn   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Articles

Functional processing of fertilin: evidence for a critical role of proteolysis in sperm maturation and activation

CP Blobel

Fertilin is a sperm surface protein with an essential role in fertilization. It is required for the migration of spermatozoa through the oviduct, for binding to the zona pellucida, and for efficient binding to the egg plasma membrane. Fertilin consists of two subunits, fertilin alpha and beta, both of which belong to the metalloprotease-disintegrin protein family (ADAMs). Fertilin alpha and beta are made as larger precursors that are processed proteolytically at different stages of sperm maturation in the testis and epididymis. Fertilin alpha is processed first, most likely by a pro-protein convertase in the secretory pathway of testicular cells. Fertilin beta is processed later, while spermatozoa are in transit through the epididymis. The processing of fertilin beta in the epididymis correlates with the acquisition of fertilization competence in spermatozoa, exposes an epitope that has a role in sperm-egg interactions, and triggers the relocalization of fertilin from the whole sperm head to the posterior head. These findings indicate that the proteolytic processing of fertilin and perhaps also other sperm proteins plays an important role in sperm maturation and activation in the epididymis. Further evaluation of the functional significance of proteolysis for sperm maturation should lead to new and exciting insights into the mechanism of sperm maturation, and may also uncover the cause of certain types of male infertility. The identification of the responsible proteases could provide novel targets for contraceptive drugs.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Delicious Delicious   Add to Digg Digg   Add to Facebook Facebook   Add to LinkedIn LinkedIn   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
Phil Trans R Soc BHome page
H. White-Cooper and N. Bausek
Evolution and spermatogenesis
Phil Trans R Soc B, May 27, 2010; 365(1546): 1465 - 1480.
[Abstract] [Full Text] [PDF]


Home page
ReproductionHome page
K. Pasten-Hidalgo, R. Hernandez-Rivas, A. L. Roa-Espitia, M. Sanchez-Gutierrez, F. Martinez-Perez, A. O. Monrroy, E. O Hernandez-Gonzalez, and A. Mujica
Presence, processing, and localization of mouse ADAM15 during sperm maturation and the role of its disintegrin domain during sperm-egg binding
Reproduction, July 1, 2008; 136(1): 41 - 51.
[Abstract] [Full Text] [PDF]


Home page
ReproductionHome page
V. Thimon, M. Belghazi, J.-L. Dacheux, and J.-L. Gatti
Analysis of furin ectodomain shedding in epididymal fluid of mammals: demonstration that shedding of furin occurs in vivo.
Reproduction, December 1, 2006; 132(6): 899 - 908.
[Abstract] [Full Text] [PDF]


Home page
Biol. Reprod.Home page
V. Thimon, S. Metayer, M. Belghazi, F. Dacheux, J.-L. Dacheux, and J.-L. Gatti
Shedding of the Germinal Angiotensin I-Converting Enzyme (gACE) Involves a Serine Protease and Is Activated by Epididymal Fluid
Biol Reprod, November 1, 2005; 73(5): 881 - 890.
[Abstract] [Full Text] [PDF]


Home page
Biol. Reprod.Home page
A. Zanich, J. C. Pascall, and R. Jones
Secreted Epididymal Glycoprotein 2D6 That Binds to the Sperm's Plasma Membrane Is a Member of the {beta}-Defensin Superfamily of Pore-Forming Glycopeptides
Biol Reprod, December 1, 2003; 69(6): 1831 - 1842.
[Abstract] [Full Text] [PDF]


Home page
FASEB J.Home page
N. A. TAYLOR, W. J. M. VAN DE VEN, and J. W. M. CREEMERS
Curbing activation: proprotein convertases in homeostasis and pathology
FASEB J, July 1, 2003; 17(10): 1215 - 1227.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
K. Peoc'h, C. Serres, Y. Frobert, C. Martin, S. Lehmann, S. Chasseigneaux, V. Sazdovitch, J. Grassi, P. Jouannet, J.-M. Launay, et al.
The Human "Prion-like" Protein Doppel Is Expressed in Both Sertoli Cells and Spermatozoa
J. Biol. Chem., November 8, 2002; 277(45): 43071 - 43078.
[Abstract] [Full Text] [PDF]


Home page
Biol. Reprod.Home page
S. Metayer, F. Dacheux, J.-L. Dacheux, and J.-L. Gatti
Comparison, Characterization, and Identification of Proteases and Protease Inhibitors in Epididymal Fluids of Domestic Mammals. Matrix Metalloproteinases Are Major Fluid Gelatinases
Biol Reprod, May 1, 2002; 66(5): 1219 - 1229.
[Abstract] [Full Text]


Home page
Biol. Reprod.Home page
J. Rutllant and S. A. Meyers
Posttranslational Processing of PH-20 During Epididymal Sperm Maturation in the Horse
Biol Reprod, November 1, 2001; 65(5): 1324 - 1331.
[Abstract] [Full Text] [PDF]


Home page
Biol. Reprod.Home page
G. Manandhar and K. Toshimori
Exposure of Sperm Head Equatorin after Acrosome Reaction and Its Fate after Fertilization in Mice
Biol Reprod, November 1, 2001; 65(5): 1425 - 1436.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
M. I. Nonaka, G. Wang, T. Mori, H. Okada, and M. Nonaka
Novel Androgen-Dependent Promoters Direct Expression of the C4b-Binding Protein {alpha}-Chain Gene in Epididymis
J. Immunol., April 1, 2001; 166(7): 4570 - 4577.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS  
Copyright © 2000 by the Society for Reproduction and Fertility.