Reviews of Reproduction
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS  

Reviews of Reproduction (2000) 5 136-142
© 2000 Society for Reproduction and Fertility
DOI: 10.1530/ror.0.0050136
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Permissions information
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sadovsky, Y
Right arrow Articles by Dorn, C
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sadovsky, Y
Right arrow Articles by Dorn, C
Social Bookmarking
 Add to CiteULike   Add to Complore   Add to Connotea   Add to Delicious   Add to Digg   Add to Facebook   Add to LinkedIn   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Articles

Function of steroidogenic factor 1 during development and differentiation of the reproductive system

Y Sadovsky and C Dorn

Intact reproductive development depends on steroids and other endocrine signals. Although recent discoveries have elucidated important steps of sexual differentiation, the intricate mechanisms that regulate the development of steroid-producing tissues remain elusive. In adults, complex feedback mechanisms determine the hypothalamic and pituitary regulation of steroid hormone biosynthesis. Steroidogenic factor 1 (SF-1), an orphan member of the nuclear receptor superfamily of proteins, plays a critical role in development and differentiation of the endocrine and reproductive systems. This review provides an overview of the function of SF-1, its mechanism of action, and a perspective on the interaction of SF-1 with other determinants of sexual differentiation. Whereas SF-1 is essential for the expression of numerous steroidogenic enzymes, its presence may not correlate with steroidogenic function. Moreover, diverse co-regulators modulate the influence of SF-1 on gene transcription. The significance of these interactions is discussed in the context of reproductive development and function. Other orphan or ligand-dependent nuclear proteins may share similar mechanisms.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Delicious Delicious   Add to Digg Digg   Add to Facebook Facebook   Add to LinkedIn LinkedIn   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
Biochem. J.Home page
L. Zhu, Y. Ke, D. Shao, Y. Cui, A. Qiao, X. Liu, F. Fang, and Y. Chang
PPAR{gamma} co-activator-1{alpha} co-activates steroidogenic factor 1 to stimulate the synthesis of luteinizing hormone and aldosterone
Biochem. J., December 15, 2010; 432(3): 473 - 486.
[Abstract] [Full Text] [PDF]


Home page
J Biol ChemHome page
I. Qamar, E.-Y. Gong, Y. Kim, C.-H. Song, H. J. Lee, S.-Y. Chun, and K. Lee
Anti-steroidogenic Factor ARR19 Inhibits Testicular Steroidogenesis through the Suppression of Nur77 Transactivation
J. Biol. Chem., July 16, 2010; 285(29): 22360 - 22369.
[Abstract] [Full Text] [PDF]


Home page
Physiol. Rev.Home page
D. Wilhelm, S. Palmer, and P. Koopman
Sex Determination and Gonadal Development in Mammals
Physiol Rev, January 1, 2007; 87(1): 1 - 28.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
Y. Li, M. Choi, K. Suino, A. Kovach, J. Daugherty, S. A. Kliewer, and H. E. Xu
Structural and biochemical basis for selective repression of the orphan nuclear receptor liver receptor homolog 1 by small heterodimer partner
PNAS, July 5, 2005; 102(27): 9505 - 9510.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
C. Y. Hong, J. H. Park, R. S. Ahn, S. Y. Im, H.-S. Choi, J. Soh, S. H. Mellon, and K. Lee
Molecular Mechanism of Suppression of Testicular Steroidogenesis by Proinflammatory Cytokine Tumor Necrosis Factor Alpha
Mol. Cell. Biol., April 1, 2004; 24(7): 2593 - 2604.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
C. Y. Hong, J. H. Park, K. H. Seo, J.-M. Kim, S. Y. Im, J. W. Lee, H.-S. Choi, and K. Lee
Expression of MIS in the Testis Is Downregulated by Tumor Necrosis Factor Alpha through the Negative Regulation of SF-1 Transactivation by NF-{kappa}B
Mol. Cell. Biol., September 1, 2003; 23(17): 6000 - 6012.
[Abstract] [Full Text] [PDF]


Home page
Biol. Reprod.Home page
K. A. Logan, K. P. McNatty, and J. L. Juengel
Expression of Wilms' Tumor Gene and Protein Localization During Ovarian Formation and Follicular Development in Sheep
Biol Reprod, February 1, 2003; 68(2): 635 - 643.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
X. Yan, J.-F. Mouillet, Q. Ou, and Y. Sadovsky
A Novel Domain within the DEAD-Box Protein DP103 Is Essential for Transcriptional Repression and Helicase Activity
Mol. Cell. Biol., January 1, 2003; 23(1): 414 - 423.
[Abstract] [Full Text] [PDF]


Home page
Biol. Reprod.Home page
K. A. Logan, J. L. Juengel, and K. P. McNatty
Onset of Steroidogenic Enzyme Gene Expression During Ovarian Follicular Development in Sheep
Biol Reprod, April 1, 2002; 66(4): 906 - 916.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS  
Copyright © 2000 by the Society for Reproduction and Fertility.